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Binding Site Geometry and Subdomain Valency Control Effects of Neutralizing Lectins on HIV‑1 Viral Particles
Carbohydrate binding proteins such as griffithsin, cyanovirin-N, and BanLec are potent HIV entry inhibitors and promising microbicides. Each binds to high-mannose glycans on the surface envelope glycoprotein gp120, yet the mechanisms by which they engage viral spikes and exhibit inhibition constants...
Shranjeno v:
| izdano v: | ACS Infect Dis |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7261407/ https://ncbi.nlm.nih.gov/pubmed/27669574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00139 |
| Oznake: |
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