Binding Site Geometry and Subdomain Valency Control Effects of Neutralizing Lectins on HIV‑1 Viral Particles

Carbohydrate binding proteins such as griffithsin, cyanovirin-N, and BanLec are potent HIV entry inhibitors and promising microbicides. Each binds to high-mannose glycans on the surface envelope glycoprotein gp120, yet the mechanisms by which they engage viral spikes and exhibit inhibition constants...

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Bibliografiska uppgifter
I publikationen:ACS Infect Dis
Huvudupphovsmän: Lusvarghi, Sabrina, Lohith, Katheryn, Morin-Leisk, Jeanne, Ghirlando, Rodolfo, Hinshaw, Jenny E., Bewley, Carole A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261407/
https://ncbi.nlm.nih.gov/pubmed/27669574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00139
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