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Binding Site Geometry and Subdomain Valency Control Effects of Neutralizing Lectins on HIV‑1 Viral Particles
Carbohydrate binding proteins such as griffithsin, cyanovirin-N, and BanLec are potent HIV entry inhibitors and promising microbicides. Each binds to high-mannose glycans on the surface envelope glycoprotein gp120, yet the mechanisms by which they engage viral spikes and exhibit inhibition constants...
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| Pubblicato in: | ACS Infect Dis |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7261407/ https://ncbi.nlm.nih.gov/pubmed/27669574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00139 |
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