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Glycopeptide Mimetics Recapitulate High-Mannose-Type Oligosaccharide Binding and Function

High-mannose-type glycans (HMTGs) decorating viral spike proteins are targets for virus neutralization. For carbohydrate-binding proteins, multivalency is important for high avidity binding and potent inhibition. To define the chemical determinants controlling multivalent interactions we designed gl...

詳細記述

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書誌詳細
出版年:Angew Chem Int Ed Engl
主要な著者: Lusvarghi, Sabrina, Ghirlando, Rodolfo, Wong, Chi-Huey, Bewley, Carole A.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260803/
https://ncbi.nlm.nih.gov/pubmed/25776945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201500157
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