INVESTIGATIONS INTO TROPOMYOSIN FUNCTION USING MOUSE MODELS

von Jagatheesan, Ganapathy, Rajan, Sudarsan, Wieczorek, David F.
Veröffentlicht 2009

Microarray analysis of active cardiac remodeling genes in a familial hypertrophic cardiomyopathy mouse model rescued by a phospholamban knockout

von Rajan, Sudarsan, Pena, James R., Jegga, Anil G., Aronow, Bruce J., Wolska, Beata M., Wieczorek, David F.
Veröffentlicht 2013

Use of 2-D DIGE analysis reveals altered phosphorylation in a tropomyosin mutant (Glu54Lys) linked to dilated cardiomyopathy

von Warren, Chad M., Arteaga, Grace M., Rajan, Sudarsan, Ahmed, Rafeeq P. H., Wieczorek, David F., Solaro, R. John
Veröffentlicht 2008

Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyos...

von Karam, Chehade N., Warren, Chad M., Rajan, Sudarsan, de Tombe, Pieter P., Wieczorek, David F., Solaro, R. John
Veröffentlicht 2011

Ligand-Specific Function of Transforming Growth Factor Beta in Epithelial-Mesenchymal Transition in Heart Development

von Azhar, Mohamad, Runyan, Raymond B., Gard, Connie, Sanford, L. Philip, Miller, Marian L., Andringa, Anastasia, Pawlowski, Sharon, Rajan, Sudarsan, Doetschman, Tom
Veröffentlicht 2009

A cellular mechanism of muscle memory facilitates mitochondrial remodelling following resistance training

von Lee, Hojun, Kim, Kijeong, Kim, Boa, Shin, Junchul, Rajan, Sudarsan, Wu, Jingwei, Chen, Xiongwen, Brown, Michael D., Lee, Sukho, Park, Joon‐Young
Veröffentlicht in J Physiol (2018)

Expression of a novel tropomyosin isoform in axolotl heart and skeletal muscle

von Thomas, Anish, Rajan, Sudarsan, Thurston, Harold L., Masineni, Sreeharsha N., Dube, Preeti, Bose, Abhishek, Muthu, Vasundhara, Dube, Syamalima, Wieczorek, David F., Dube, Dipak K.
Veröffentlicht 2010

Transforming growth factor Beta2 is required for valve remodeling during heart development

von Azhar, Mohamad, Brown, Kristen, Gard, Connie, Chen, Hwudaurw, Rajan, Sudarsan, Elliott, David A., Stevens, Mark V., Camenisch, Todd D., Conway, Simon J., Doetschman, Thomas
Veröffentlicht 2011

Structural insights into mitochondrial calcium uniporter regulation by divalent cations

von Lee, Samuel K., Shanmughapriya, Santhanam, Mok, Mac C.Y., Dong, Zhiwei, Tomar, Dhanendra, Carvalho, Edmund, Rajan, Sudarsan, Junop, Murray S., Madesh, Muniswamy, Stathopulos, Peter B.
Veröffentlicht in Cell Chem Biol (2016)

Constructing and Evaluating Caspase-Activatable Adeno-Associated Virus Vector for Gene Delivery to Injured Heart

von Brun, Mitchell J, Song, Kefan, Kang, Byunguk, Lueck, Cooper, Chen, Weitong, Thatcher, Kaitlyn, Gao, Erhe, Koch, Walter J, Lincoln, Joy, Rajan, Sudarsan, Suh, Junghae
Veröffentlicht in J Control Release (2020)

Tropomyosin pseudo-phosphorylation results in dilated cardiomyopathy

von Rajan, Sudarsan, Jagatheesan, Ganapathy, Petrashevskaya, Natalia, Biesiadecki, Brandon J., Warren, Chad M., Riddle, Tara, Liggett, Stephen, Wolska, Beata M., Solaro, R. John, Wieczorek, David F.
Veröffentlicht in J Biol Chem (2019)

Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity

von Jagatheesan, Ganapathy, Rajan, Sudarsan, Ahmed, Rafeeq P. H., Petrashevskaya, Natalia, Boivin, Greg, Arteaga, Grace M., Tae, Hyun-Jin, Liggett, Stephen B., Solaro, R. John, Wieczorek, David F.
Veröffentlicht 2010

Conserved Asp-137 Is Important for both Structure and Regulatory Functions of Cardiac α-Tropomyosin (α-TM) in a Novel Transgenic Mouse Model Expressing α-TM-D137L

von Yar, Sumeyye, Chowdhury, Shamim A. K., Davis, Robert T., Kobayashi, Minae, Monasky, Michelle M., Rajan, Sudarsan, Wolska, Beata M., Gaponenko, Vadim, Kobayashi, Tomoyoshi, Wieczorek, David F., Solaro, R. John
Veröffentlicht 2013

LETM1-dependent mitochondrial Ca(2+) flux modulates cellular bioenergetics and proliferation

von Doonan, Patrick J., Chandramoorthy, Harish C., Hoffman, Nicholas E., Zhang, Xueqian, Cárdenas, César, Shanmughapriya, Santhanam, Rajan, Sudarsan, Vallem, Sandhya, Chen, Xiongwen, Foskett, J. Kevin, Cheung, Joseph Y., Houser, Steven R., Madesh, Muniswamy
Veröffentlicht 2014

SLC25A23 augments mitochondrial Ca(2+) uptake, interacts with MCU, and induces oxidative stress–mediated cell death

von Hoffman, Nicholas E., Chandramoorthy, Harish C., Shanmughapriya, Santhanam, Zhang, Xueqian Q., Vallem, Sandhya, Doonan, Patrick J., Malliankaraman, Karthik, Guo, Shuchi, Rajan, Sudarsan, Elrod, John W., Koch, Walter J., Cheung, Joseph Y., Madesh, Muniswamy
Veröffentlicht 2014

Acute and Chronic Increases of Circulating Follistatin-like Protein 1 Normalize Energy Substrate Metabolism in Pacing-Induced Heart Failure

von Seki, Mitsuru, Powers, Jeffery C., Maruyama, Sonomi, Zuriaga, Maria A., Wu, Chia-Ling, Kurishima, Clara, Kim, Lydia, Johnson, Jesse, Poidomani, Anthony, Wang, Tao, Muñoz, Eric, Rajan, Sudarsan, Park, Joon Y., Walsh, Kenneth, Recchia, Fabio A.
Veröffentlicht in Circ Heart Fail (2018)

Myocardial Infarction-induced N-terminal Fragment of Cardiac Myosin-binding Protein C (cMyBP-C) Impairs Myofilament Function in Human Myocardium

von Witayavanitkul, Namthip, Ait Mou, Younss, Kuster, Diederik W. D., Khairallah, Ramzi J., Sarkey, Jason, Govindan, Suresh, Chen, Xin, Ge, Ying, Rajan, Sudarsan, Wieczorek, David F., Irving, Thomas, Westfall, Margaret V., de Tombe, Pieter P., Sadayappan, Sakthivel
Veröffentlicht 2014

Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy

von Zhou, Jibin, Ahmad, Firdos, Parikh, Shan, Hoffman, Nichole E., Rajan, Sudarsan, Verma, Vipin K., Song, Jianliang, Yuan, Ancai, Shanmughapriya, Santhanam, Guo, Yuanjun, Gao, Erhe, Koch, Walter, Woodgett, James R., Muniswamy, Madesh, Kishore, Raj, Lal, Hind, Force, Thomas
Veröffentlicht in Circ Res (2016)

MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

von Hoffman, Nicholas E., Chandramoorthy, Harish C., Shamugapriya, Santhanam, Zhang, Xueqian, Rajan, Sudarsan, Mallilankaraman, Karthik, Gandhirajan, Rajesh Kumar, Vagnozzi, Ronald J., Ferrer, Lukas M., Sreekrishnanilayam, Krishnalatha, Natarajaseenivasan, Kalimuthusamy, Vallem, Sandhya, Force, Thomas, Choi, Eric T., Cheung, Joseph Y., Madesh, Muniswamy
Veröffentlicht 2013

An internal domain of β-tropomyosin increases myofilament Ca(2+) sensitivity

von Jagatheesan, Ganapathy, Rajan, Sudarsan, Schulz, Emily M., Ahmed, Rafeeq P. H., Petrashevskaya, Natalia, Schwartz, Arnold, Boivin, Greg P., Arteaga, Grace M., Wang, Tao, Wang, Yi-Gang, Ashraf, Muhammad, Liggett, Stephen B., Lorenz, John, Solaro, R. John, Wieczorek, David F.
Veröffentlicht 2009