Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy

RATIONALE: Cardiac myocyte-specific deletion of either Glycogen Synthase Kinase (GSK)3A or GSK3B leads to cardiac protection following myocardial infarction, suggesting that deletion of both isoforms may provide synergistic protection. This is an important consideration due to the fact that all GSK-...

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Pubblicato in:Circ Res
Autori principali: Zhou, Jibin, Ahmad, Firdos, Parikh, Shan, Hoffman, Nichole E., Rajan, Sudarsan, Verma, Vipin K., Song, Jianliang, Yuan, Ancai, Shanmughapriya, Santhanam, Guo, Yuanjun, Gao, Erhe, Koch, Walter, Woodgett, James R., Muniswamy, Madesh, Kishore, Raj, Lal, Hind, Force, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843504/
https://ncbi.nlm.nih.gov/pubmed/26976650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.308544
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