Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy

RATIONALE: Cardiac myocyte-specific deletion of either Glycogen Synthase Kinase (GSK)3A or GSK3B leads to cardiac protection following myocardial infarction, suggesting that deletion of both isoforms may provide synergistic protection. This is an important consideration due to the fact that all GSK-...

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Veröffentlicht in:Circ Res
Hauptverfasser: Zhou, Jibin, Ahmad, Firdos, Parikh, Shan, Hoffman, Nichole E., Rajan, Sudarsan, Verma, Vipin K., Song, Jianliang, Yuan, Ancai, Shanmughapriya, Santhanam, Guo, Yuanjun, Gao, Erhe, Koch, Walter, Woodgett, James R., Muniswamy, Madesh, Kishore, Raj, Lal, Hind, Force, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843504/
https://ncbi.nlm.nih.gov/pubmed/26976650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.308544
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