GSK-3α is a central regulator of age-related pathologies in mice

Aging is regulated by conserved signaling pathways. The glycogen synthase kinase-3 (GSK-3) family of serine/threonine kinases regulates several of these pathways, but the role of GSK-3 in aging is unknown. Herein, we demonstrate premature death and acceleration of age-related pathologies in the Gsk3...

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Détails bibliographiques
Auteurs principaux: Zhou, Jibin, Freeman, Theresa A., Ahmad, Firdos, Shang, Xiying, Mangano, Emily, Gao, Erhe, Farber, John, Wang, Yajing, Ma, Xin-Liang, Woodgett, James, Vagnozzi, Ronald J., Lal, Hind, Force, Thomas
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613907/
https://ncbi.nlm.nih.gov/pubmed/23549082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64398
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