MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

Resting mitochondrial matrix Ca(2+) is maintained through a MICU1-established threshold inhibition of MCU activity. It is not known how MICU1 interacts with MCU to establish this Ca(2+) threshold for mitochondrial Ca(2+) uptake and MCU activity. Here, we show that MICU1 localizes to the mitochondria...

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Main Authors: Hoffman, Nicholas E., Chandramoorthy, Harish C., Shamugapriya, Santhanam, Zhang, Xueqian, Rajan, Sudarsan, Mallilankaraman, Karthik, Gandhirajan, Rajesh Kumar, Vagnozzi, Ronald J., Ferrer, Lukas M., Sreekrishnanilayam, Krishnalatha, Natarajaseenivasan, Kalimuthusamy, Vallem, Sandhya, Force, Thomas, Choi, Eric T., Cheung, Joseph Y., Madesh, Muniswamy
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919628/
https://ncbi.nlm.nih.gov/pubmed/24332854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.11.026
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