MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

Resting mitochondrial matrix Ca(2+) is maintained through a MICU1-established threshold inhibition of MCU activity. It is not known how MICU1 interacts with MCU to establish this Ca(2+) threshold for mitochondrial Ca(2+) uptake and MCU activity. Here, we show that MICU1 localizes to the mitochondria...

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Detaylı Bibliyografya
Asıl Yazarlar: Hoffman, Nicholas E., Chandramoorthy, Harish C., Shamugapriya, Santhanam, Zhang, Xueqian, Rajan, Sudarsan, Mallilankaraman, Karthik, Gandhirajan, Rajesh Kumar, Vagnozzi, Ronald J., Ferrer, Lukas M., Sreekrishnanilayam, Krishnalatha, Natarajaseenivasan, Kalimuthusamy, Vallem, Sandhya, Force, Thomas, Choi, Eric T., Cheung, Joseph Y., Madesh, Muniswamy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919628/
https://ncbi.nlm.nih.gov/pubmed/24332854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.11.026
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