MICU1 is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca(2+) Uptake That Regulates Cell Survival

Mitochondrial Ca(2+) (Ca(2+)(m)) uptake is mediated by an inner membrane Ca(2+) channel called the uniporter. Ca(2+) uptake is driven by the considerable voltage present across the inner membrane (ΔΨ(m)) generated by proton pumping by the respiratory chain. Mitochondrial matrix Ca(2+) concentration...

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Main Authors: Mallilankaraman, Karthik, Doonan, Patrick, Cárdenas, César, Chandramoorthy, Harish C., Muller, Marioly, Miller, Russell, Hoffman, Nicholas E., Gandhirajan, Rajesh, Molgó, Jordi, Birnbaum, Morris J., Rothberg, Brad, Mak, Don-On Daniel, Foskett, J. Kevin, Madesh, Muniswamy
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486697/
https://ncbi.nlm.nih.gov/pubmed/23101630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.10.011
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