Conserved Asp-137 Is Important for both Structure and Regulatory Functions of Cardiac α-Tropomyosin (α-TM) in a Novel Transgenic Mouse Model Expressing α-TM-D137L

α-Tropomyosin (α-TM) has a conserved, charged Asp-137 residue located in the hydrophobic core of its coiled-coil structure, which is unusual in that the residue is found at a position typically occupied by a hydrophobic residue. Asp-137 is thought to destabilize the coiled-coil and so impart structu...

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Autors principals: Yar, Sumeyye, Chowdhury, Shamim A. K., Davis, Robert T., Kobayashi, Minae, Monasky, Michelle M., Rajan, Sudarsan, Wolska, Beata M., Gaponenko, Vadim, Kobayashi, Tomoyoshi, Wieczorek, David F., Solaro, R. John
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675563/
https://ncbi.nlm.nih.gov/pubmed/23609439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.458695
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