Structural insights into mitochondrial calcium uniporter regulation by divalent cations

Calcium (Ca(2+)) flux into the matrix is tightly controlled by the mitochondrial Ca(2+) uniporter (MCU) due to vital roles in cell death and bioenergetics. However, the precise atomic mechanisms of MCU regulation remain unclear. Here, we solved the crystal structure of the N-terminal matrix domain o...

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Publicat a:Cell Chem Biol
Autors principals: Lee, Samuel K., Shanmughapriya, Santhanam, Mok, Mac C.Y., Dong, Zhiwei, Tomar, Dhanendra, Carvalho, Edmund, Rajan, Sudarsan, Junop, Murray S., Madesh, Muniswamy, Stathopulos, Peter B.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035232/
https://ncbi.nlm.nih.gov/pubmed/27569754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.07.012
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