A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

[Image: see text] Mitochondrial Ca(2+) ((m)Ca(2+)) uptake mediated by the mitochondrial calcium uniporter (MCU) plays a critical role in signal transduction, bioenergetics, and cell death, and its dysregulation is linked to several human diseases. In this study, we report a new ruthenium complex Ru2...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Woods, Joshua J., Nemani, Neeharika, Shanmughapriya, Santhanam, Kumar, Akshay, Zhang, MengQi, Nathan, Sarah R., Thomas, Manfred, Carvalho, Edmund, Ramachandran, Karthik, Srikantan, Subramanya, Stathopulos, Peter B., Wilson, Justin J., Madesh, Muniswamy
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6346394/
https://ncbi.nlm.nih.gov/pubmed/30693334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.8b00773
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