Mitochondrial Pyruvate and Fatty Acid Flux Modulate MICU1-Dependent Control of MCU Activity

The tricarboxylic acid (TCA) cycle converts the end products of glycolysis and fatty acid β-oxidation into the reducing equivalents NADH and FADH(2). Although mitochondrial matrix uptake of Ca(2+) enhances ATP production, it remains unclear whether deprivation of mitochondrial TCA substrates alters...

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Publicat a:Sci Signal
Autors principals: Nemani, Neeharika, Dong, Zhiwei, Daw, Cassidy C., Madaris, Travis R., Ramachandran, Karthik, Enslow, Benjamin T., Rubannelsonkumar, Cherubina S., Shanmughapriya, Santhanam, Mallireddigari, Varshini, Maity, Soumya, SinghMalla, Pragya, Natarajanseenivasan, Kalimuthusamy, Hooper, Robert, Shannon, Christopher E., Tourtellotte, Warren G., Singh, Brij B., Reeves, Brian W., Sharma, Kumar, Norton, Luke, Srikantan, Subramanya, Soboloff, Johnathan, Madesh, Muniswamy
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667998/
https://ncbi.nlm.nih.gov/pubmed/32317369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaz6206
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