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Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

Impairments in neuronal intracellular calcium ((i)Ca(2+)) handling may contribute to Alzheimer’s disease (AD) development. Metabolic dysfunction and progressive neuronal loss are associated with AD progression, and mitochondrial calcium ((m)Ca(2+)) signaling is a key regulator of both of these proce...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Jadiya, Pooja, Kolmetzky, Devin W., Tomar, Dhanendra, Di Meco, Antonio, Lombardi, Alyssa A., Lambert, Jonathan P., Luongo, Timothy S., Ludtmann, Marthe H., Praticò, Domenico, Elrod, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715724/
https://ncbi.nlm.nih.gov/pubmed/31467276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11813-6
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