Molecular pharmacology in a simple model system: Implicating MAP kinase and phosphoinositide signalling in bipolar disorder

Por Ludtmann, Marthe H.R., Boeckeler, Katrina, Williams, Robin S.B.
Publicado em 2011

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

Por Ludtmann, Marthe H. R., Angelova, Plamena R., Zhang, Ying, Abramov, Andrey Y., Dinkova-Kostova, Albena T.
Publicado em 2014

LRRK2 deficiency induced mitochondrial Ca(2+) efflux inhibition can be rescued by Na(+)/Ca(2+)/Li(+) exchanger upregulation

Por Ludtmann, Marthe H. R., Kostic, Marko, Horne, Amy, Gandhi, Sonia, Sekler, Israel, Abramov, Andrey Y.
Publicado no Cell Death Dis (2019)

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase

Por Ludtmann, Marthe H.R., Angelova, Plamena R., Ninkina, Natalia N., Gandhi, Sonia, Buchman, Vladimir L., Abramov, Andrey Y.
Publicado no J Neurosci (2016)

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons

Por Kostic, Marko, Ludtmann, Marthe H.R., Bading, Hilmar, Hershfinkel, Michal, Steer, Erin, Chu, Charleen T., Abramov, Andrey Y., Sekler, Israel
Publicado no Cell Rep (2015)

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons

Por Ludtmann, Marthe H. R., Arber, Charles, Bartolome, Fernando, de Vicente, Macarena, Preza, Elisavet, Carro, Eva, Houlden, Henry, Gandhi, Sonia, Wray, Selina, Abramov, Andrey Y.
Publicado no J Biol Chem (2017)

Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function

Por Neary, Marianne T., Ng, Keat-Eng, Ludtmann, Marthe H.R., Hall, Andrew R., Piotrowska, Izabela, Ong, Sang-Bing, Hausenloy, Derek J., Mohun, Timothy J., Abramov, Andrey Y., Breckenridge, Ross A.
Publicado em 2014

An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum

Por Ludtmann, Marthe H. R., Otto, Grant P., Schilde, Christina, Chen, Zhi-Hui, Allan, Claire Y., Brace, Selina, Beesley, Philip W., Kimmel, Alan R., Fisher, Paul, Killick, Richard, Williams, Robin S. B.
Publicado em 2014

Ca(2+) is a key factor in α-synuclein-induced neurotoxicity

Por Angelova, Plamena R., Ludtmann, Marthe H. R., Horrocks, Mathew H., Negoda, Alexander, Cremades, Nunilo, Klenerman, David, Dobson, Christopher M., Wood, Nicholas W., Pavlov, Evgeny V., Gandhi, Sonia, Abramov, Andrey Y.
Publicado no J Cell Sci (2016)

Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury

Por Siddall, Hilary K., Yellon, Derek M., Ong, Sang-Bing, Mukherjee, Uma A., Burke, Niall, Hall, Andrew R., Angelova, Plamena R., Ludtmann, Marthe H. R., Deas, Emma, Davidson, Sean M., Mocanu, Mihaela M., Hausenloy, Derek J.
Publicado em 2013

Correction: Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury

Por Siddall, Hilary K., Yellon, Derek M., Ong, Sang-Bing, Mukherjee, Uma A., Burke, Niall, Hall, Andrew R., Angelova, Plamena R., Ludtmann, Marthe H. R., Deas, Emma, Davidson, Sean M., Mocanu, Mihaela M., Hausenloy, Derek J.
Publicado em 2013

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

Por Deas, Emma, Cremades, Nunilo, Angelova, Plamena R., Ludtmann, Marthe H.R., Yao, Zhi, Chen, Serene, Horrocks, Mathew H., Banushi, Blerida, Little, Daniel, Devine, Michael J., Gissen, Paul, Klenerman, David, Dobson, Christopher M., Wood, Nicholas W., Gandhi, Sonia, Abramov, Andrey Y.
Publicado no Antioxid Redox Signal (2016)

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

Por Iljina, Marija, Hong, Liu, Horrocks, Mathew H., Ludtmann, Marthe H., Choi, Minee L., Hughes, Craig D., Ruggeri, Francesco S., Guilliams, Tim, Buell, Alexander K., Lee, Ji-Eun, Gandhi, Sonia, Lee, Steven F., Bryant, Clare E., Vendruscolo, Michele, Knowles, Tuomas P. J., Dobson, Christopher M., De Genst, Erwin, Klenerman, David
Publicado no BMC Biol (2017)

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

Por Ludtmann, Marthe H. R., Angelova, Plamena R., Horrocks, Mathew H., Choi, Minee L., Rodrigues, Margarida, Baev, Artyom Y., Berezhnov, Alexey V., Yao, Zhi, Little, Daniel, Banushi, Blerida, Al-Menhali, Afnan Saleh, Ranasinghe, Rohan T., Whiten, Daniel R., Yapom, Ratsuda, Dolt, Karamjit Singh, Devine, Michael J., Gissen, Paul, Kunath, Tilo, Jaganjac, Morana, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia
Publicado no Nat Commun (2018)

Clinical, pathological and functional characterization of riboflavin-responsive neuropathy

Por Manole, Andreea, Jaunmuktane, Zane, Hargreaves, Iain, Ludtmann, Marthe H R, Salpietro, Vincenzo, Bello, Oscar D, Pope, Simon, Pandraud, Amelie, Horga, Alejandro, Scalco, Renata S, Li, Abi, Ashokkumar, Balasubramaniem, Lourenço, Charles M, Heales, Simon, Horvath, Rita, Chinnery, Patrick F, Toro, Camilo, Singleton, Andrew B, Jacques, Thomas S, Abramov, Andrey Y, Muntoni, Francesco, Hanna, Michael G, Reilly, Mary M, Revesz, Tamas, Kullmann, Dimitri M, Jepson, James E C, Houlden, Henry
Publicado no Brain (2017)

A Missense Mutation in KCTD17 Causes Autosomal Dominant Myoclonus-Dystonia

Por Mencacci, Niccolo E., Rubio-Agusti, Ignacio, Zdebik, Anselm, Asmus, Friedrich, Ludtmann, Marthe H.R., Ryten, Mina, Plagnol, Vincent, Hauser, Ann-Kathrin, Bandres-Ciga, Sara, Bettencourt, Conceição, Forabosco, Paola, Hughes, Deborah, Soutar, Marc M.P., Peall, Kathryn, Morris, Huw R., Trabzuni, Daniah, Tekman, Mehmet, Stanescu, Horia C., Kleta, Robert, Carecchio, Miryam, Zorzi, Giovanna, Nardocci, Nardo, Garavaglia, Barbara, Lohmann, Ebba, Weissbach, Anne, Klein, Christine, Hardy, John, Pittman, Alan M., Foltynie, Thomas, Abramov, Andrey Y., Gasser, Thomas, Bhatia, Kailash P., Wood, Nicholas W.
Publicado no Am J Hum Genet (2015)