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LRRK2 deficiency induced mitochondrial Ca(2+) efflux inhibition can be rescued by Na(+)/Ca(2+)/Li(+) exchanger upregulation
Variants of leucine-rich repeat kinase 2 (lrrk2) are associated with an increased risk in developing Parkinson’s disease (PD). Mitochondrial dysfunction and specifically mitochondrial Ca(2+) handling has been linked to the pathogenesis of PD. Here we describe for the second time a mitochondrial Ca(2...
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| Udgivet i: | Cell Death Dis |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6424963/ https://ncbi.nlm.nih.gov/pubmed/30890692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1469-5 |
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