Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury

OBJECTIVES: Mutations in PTEN inducible kinase-1 (PINK1) induce mitochondrial dysfunction in dopaminergic neurons resulting in an inherited form of Parkinson’s disease. Although PINK1 is present in the heart its exact role there is unclear. We hypothesized that PINK1 protects the heart against acute...

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Detalhes bibliográficos
Main Authors: Siddall, Hilary K., Yellon, Derek M., Ong, Sang-Bing, Mukherjee, Uma A., Burke, Niall, Hall, Andrew R., Angelova, Plamena R., Ludtmann, Marthe H. R., Deas, Emma, Davidson, Sean M., Mocanu, Mihaela M., Hausenloy, Derek J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639249/
https://ncbi.nlm.nih.gov/pubmed/23638067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062400
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