Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury

OBJECTIVES: Mutations in PTEN inducible kinase-1 (PINK1) induce mitochondrial dysfunction in dopaminergic neurons resulting in an inherited form of Parkinson’s disease. Although PINK1 is present in the heart its exact role there is unclear. We hypothesized that PINK1 protects the heart against acute...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Siddall, Hilary K., Yellon, Derek M., Ong, Sang-Bing, Mukherjee, Uma A., Burke, Niall, Hall, Andrew R., Angelova, Plamena R., Ludtmann, Marthe H. R., Deas, Emma, Davidson, Sean M., Mocanu, Mihaela M., Hausenloy, Derek J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2013
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639249/
https://ncbi.nlm.nih.gov/pubmed/23638067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062400
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