Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

Aims: Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregation of alpha-synuclein (α-S) from its mo...

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Publicado en:Antioxid Redox Signal
Autores principales: Deas, Emma, Cremades, Nunilo, Angelova, Plamena R., Ludtmann, Marthe H.R., Yao, Zhi, Chen, Serene, Horrocks, Mathew H., Banushi, Blerida, Little, Daniel, Devine, Michael J., Gissen, Paul, Klenerman, David, Dobson, Christopher M., Wood, Nicholas W., Gandhi, Sonia, Abramov, Andrey Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2016
Materias:
Original Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999647/
https://ncbi.nlm.nih.gov/pubmed/26564470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2015.6343
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