Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

Aims: Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregation of alpha-synuclein (α-S) from its mo...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Deas, Emma, Cremades, Nunilo, Angelova, Plamena R., Ludtmann, Marthe H.R., Yao, Zhi, Chen, Serene, Horrocks, Mathew H., Banushi, Blerida, Little, Daniel, Devine, Michael J., Gissen, Paul, Klenerman, David, Dobson, Christopher M., Wood, Nicholas W., Gandhi, Sonia, Abramov, Andrey Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999647/
https://ncbi.nlm.nih.gov/pubmed/26564470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2015.6343
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