Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

We describe the isolation and detailed structural characterization of stable toxic oligomers of α-synuclein that have accumulated during the process of amyloid formation. Our approach has allowed us to identify distinct subgroups of oligomers and to probe their molecular architectures by using cryo-...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Chen, Serene W., Drakulic, Srdja, Deas, Emma, Ouberai, Myriam, Aprile, Francesco A., Arranz, Rocío, Ness, Samuel, Roodveldt, Cintia, Guilliams, Tim, De-Genst, Erwin J., Klenerman, David, Wood, Nicholas W., Knowles, Tuomas P.J., Alfonso, Carlos, Rivas, Germán, Abramov, Andrey Y., Valpuesta, José María, Dobson, Christopher M., Cremades, Nunilo
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413268/
https://ncbi.nlm.nih.gov/pubmed/25855634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421204112
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