The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

The self-assembly of α-synuclein (αS) into intraneuronal inclusion bodies is a key characteristic of Parkinson’s disease. To define the nature of the species giving rise to neuronal damage, we have investigated the mechanism of action of the main αS populations that have been observed to form progre...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Cascella, Roberta, Chen, Serene W., Bigi, Alessandra, Camino, José D., Xu, Catherine K., Dobson, Christopher M., Chiti, Fabrizio, Cremades, Nunilo, Cecchi, Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985515/
https://ncbi.nlm.nih.gov/pubmed/33753734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21937-3
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