Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies

Por Cascella, Roberta, Capitini, Claudia, Fani, Giulia, Dobson, Christopher M., Cecchi, Cristina, Chiti, Fabrizio
Publicado no J Biol Chem (2016)

Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases

Por Evangelisti, Elisa, Cascella, Roberta, Becatti, Matteo, Marrazza, Giovanna, Dobson, Christopher M., Chiti, Fabrizio, Stefani, Massimo, Cecchi, Cristina
Publicado no Sci Rep (2016)

SIRT1 regulates MAPK pathways in vitiligo skin: insight into the molecular pathways of cell survival

Por Becatti, Matteo, Fiorillo, Claudia, Barygina, Victoria, Cecchi, Cristina, Lotti, Torello, Prignano, Francesca, Silvestro, Agrippino, Nassi, Paolo, Taddei, Niccolò
Publicado em 2014

Interaction of toxic and non-toxic HypF-N oligomers with lipid bilayers investigated at high resolution with atomic force microscopy

Por Oropesa-Nuñez, Reinier, Seghezza, Silvia, Dante, Silvia, Diaspro, Alberto, Cascella, Roberta, Cecchi, Cristina, Stefani, Massimo, Chiti, Fabrizio, Canale, Claudio
Publicado no Oncotarget (2016)

TDP-43 Inclusion Bodies Formed in Bacteria Are Structurally Amorphous, Non-Amyloid and Inherently Toxic to Neuroblastoma Cells

Por Capitini, Claudia, Conti, Simona, Perni, Michele, Guidi, Francesca, Cascella, Roberta, De Poli, Angela, Penco, Amanda, Relini, Annalisa, Cecchi, Cristina, Chiti, Fabrizio
Publicado em 2014

A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells

Por Zampagni, Mariagioia, Cascella, Roberta, Casamenti, Fiorella, Grossi, Cristina, Evangelisti, Elisa, Wright, Daniel, Becatti, Matteo, Liguri, Gianfranco, Mannini, Benedetta, Campioni, Silvia, Chiti, Fabrizio, Cecchi, Cristina
Publicado no J Cell Mol Med (2011)

Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia

Por Scognamiglio, Pasqualina Liana, Di Natale, Concetta, Leone, Marilisa, Cascella, Roberta, Cecchi, Cristina, Lirussi, Lisa, Antoniali, Giulia, Riccardi, Domenico, Morelli, Giancarlo, Tell, Gianluca, Chiti, Fabrizio, Marasco, Daniela
Publicado no Oncotarget (2016)

Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers

Por Mannini, Benedetta, Cascella, Roberta, Zampagni, Mariagioia, van Waarde-Verhagen, Maria, Meehan, Sarah, Roodveldt, Cintia, Campioni, Silvia, Boninsegna, Matilde, Penco, Amanda, Relini, Annalisa, Kampinga, Harm H., Dobson, Christopher M., Wilson, Mark R., Cecchi, Cristina, Chiti, Fabrizio
Publicado em 2012

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

Por Perni, Michele, Galvagnion, Céline, Maltsev, Alexander, Meisl, Georg, Müller, Martin B. D., Challa, Pavan K., Kirkegaard, Julius B., Flagmeier, Patrick, Cohen, Samuel I. A., Cascella, Roberta, Chen, Serene W., Limbocker, Ryan, Sormanni, Pietro, Heller, Gabriella T., Aprile, Francesco A., Cremades, Nunilo, Cecchi, Cristina, Chiti, Fabrizio, Nollen, Ellen A. A., Knowles, Tuomas P. J., Vendruscolo, Michele, Bax, Adriaan, Zasloff, Michael, Dobson, Christopher M.
Publicado no Proc Natl Acad Sci U S A (2017)