Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers

Chaperones are the primary regulators of the proteostasis network and are known to facilitate protein folding, inhibit protein aggregation, and promote disaggregation and clearance of misfolded aggregates inside cells. We have tested the effects of five chaperones on the toxicity of misfolded oligom...

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Detalles Bibliográficos
Autores principales: Mannini, Benedetta, Cascella, Roberta, Zampagni, Mariagioia, van Waarde-Verhagen, Maria, Meehan, Sarah, Roodveldt, Cintia, Campioni, Silvia, Boninsegna, Matilde, Penco, Amanda, Relini, Annalisa, Kampinga, Harm H., Dobson, Christopher M., Wilson, Mark R., Cecchi, Cristina, Chiti, Fabrizio
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411936/
https://ncbi.nlm.nih.gov/pubmed/22802614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117799109
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