Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers

Chaperones are the primary regulators of the proteostasis network and are known to facilitate protein folding, inhibit protein aggregation, and promote disaggregation and clearance of misfolded aggregates inside cells. We have tested the effects of five chaperones on the toxicity of misfolded oligom...

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Detalhes bibliográficos
Main Authors: Mannini, Benedetta, Cascella, Roberta, Zampagni, Mariagioia, van Waarde-Verhagen, Maria, Meehan, Sarah, Roodveldt, Cintia, Campioni, Silvia, Boninsegna, Matilde, Penco, Amanda, Relini, Annalisa, Kampinga, Harm H., Dobson, Christopher M., Wilson, Mark R., Cecchi, Cristina, Chiti, Fabrizio
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411936/
https://ncbi.nlm.nih.gov/pubmed/22802614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117799109
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