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Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin positive inclusions (FTLD-U) are two clinically distinct neurodegenerative conditions sharing a similar histopathology characterized by the nuclear clearance of TDP-43 and its associated deposition into cytoplas...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Cascella, Roberta, Capitini, Claudia, Fani, Giulia, Dobson, Christopher M., Cecchi, Cristina, Chiti, Fabrizio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016682/
https://ncbi.nlm.nih.gov/pubmed/27445339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.737726
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