Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy

por Pinotsi, Dorothea, Buell, Alexander K., Galvagnion, Celine, Dobson, Christopher M., Kaminski Schierle, Gabriele S., Kaminski, Clemens F.
Publicado 2013

Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils

por Galvagnion, Céline, Topgaard, Daniel, Makasewicz, Katarzyna, Buell, Alexander K., Linse, Sara, Sparr, Emma, Dobson, Christopher M.
Publicado en J Phys Chem Lett (2019)

The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments

por Granata, Daniele, Baftizadeh, Fahimeh, Habchi, Johnny, Galvagnion, Celine, De Simone, Alfonso, Camilloni, Carlo, Laio, Alessandro, Vendruscolo, Michele
Publicado en Sci Rep (2015)

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH

por van der Wateren, Ingrid M., Knowles, Tuomas P. J., Buell, Alexander K., Dobson, Christopher M., Galvagnion, Céline
Publicado en Chem Sci (2018)

α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling

por Ouberai, Myriam M., Wang, Juan, Swann, Marcus J., Galvagnion, Celine, Guilliams, Tim, Dobson, Christopher M., Welland, Mark E.
Publicado 2013

Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation

por Flagmeier, Patrick, Meisl, Georg, Vendruscolo, Michele, Knowles, Tuomas P. J., Dobson, Christopher M., Buell, Alexander K., Galvagnion, Céline
Publicado en Proc Natl Acad Sci U S A (2016)

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

por Galvagnion, Céline, Buell, Alexander K., Meisl, Georg, Michaels, Thomas C.T., Vendruscolo, Michele, Knowles, Tuomas P.J., Dobson, Christopher M.
Publicado en Nat Chem Biol (2015)

Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

por Buell, Alexander K., Galvagnion, Céline, Gaspar, Ricardo, Sparr, Emma, Vendruscolo, Michele, Knowles, Tuomas P. J., Linse, Sara, Dobson, Christopher M.
Publicado 2014

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

por Galvagnion, Céline, Brown, James W. P., Ouberai, Myriam M., Flagmeier, Patrick, Vendruscolo, Michele, Buell, Alexander K., Sparr, Emma, Dobson, Christopher M.
Publicado en Proc Natl Acad Sci U S A (2016)

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces

por Brown, James W. P., Buell, Alexander K., Michaels, Thomas C. T., Meisl, Georg, Carozza, Jacqueline, Flagmeier, Patrick, Vendruscolo, Michele, Knowles, Tuomas P. J., Dobson, Christopher M., Galvagnion, Céline
Publicado en Sci Rep (2016)

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

por Chattopadhyay, Anasuya, O’Connor, Cornelius J., Zhang, Fengzhi, Galvagnion, Celine, Galloway, Warren R. J. D., Tan, Yaw Sing, Stokes, Jamie E., Rahman, Taufiq, Verma, Chandra, Spring, David R., Itzhaki, Laura S.
Publicado en Sci Rep (2016)

An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

por Agerschou, Emil Dandanell, Flagmeier, Patrick, Saridaki, Theodora, Galvagnion, Céline, Komnig, Daniel, Heid, Laetitia, Prasad, Vibha, Shaykhalishahi, Hamed, Willbold, Dieter, Dobson, Christopher M, Voigt, Aaron, Falkenburger, Bjoern, Hoyer, Wolfgang, Buell, Alexander K
Publicado en eLife (2019)

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

por Perni, Michele, Galvagnion, Céline, Maltsev, Alexander, Meisl, Georg, Müller, Martin B. D., Challa, Pavan K., Kirkegaard, Julius B., Flagmeier, Patrick, Cohen, Samuel I. A., Cascella, Roberta, Chen, Serene W., Limbocker, Ryan, Sormanni, Pietro, Heller, Gabriella T., Aprile, Francesco A., Cremades, Nunilo, Cecchi, Cristina, Chiti, Fabrizio, Nollen, Ellen A. A., Knowles, Tuomas P. J., Vendruscolo, Michele, Bax, Adriaan, Zasloff, Michael, Dobson, Christopher M.
Publicado en Proc Natl Acad Sci U S A (2017)

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

por Tóth, Gergely, Gardai, Shyra J., Zago, Wagner, Bertoncini, Carlos W., Cremades, Nunilo, Roy, Susan L., Tambe, Mitali A., Rochet, Jean-Christophe, Galvagnion, Celine, Skibinski, Gaia, Finkbeiner, Steven, Bova, Michael, Regnstrom, Karin, Chiou, San-San, Johnston, Jennifer, Callaway, Kari, Anderson, John P., Jobling, Michael F., Buell, Alexander K., Yednock, Ted A., Knowles, Tuomas P. J., Vendruscolo, Michele, Christodoulou, John, Dobson, Christopher M., Schenk, Dale, McConlogue, Lisa
Publicado 2014