Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

Gankyrin is an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. Elevated gankyrin levels are linked to aberrant cellular events including enhanced degradation of tumour suppressor protein p53, and inhibition of gankyrin activity has therefo...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chattopadhyay, Anasuya, O’Connor, Cornelius J., Zhang, Fengzhi, Galvagnion, Celine, Galloway, Warren R. J. D., Tan, Yaw Sing, Stokes, Jamie E., Rahman, Taufiq, Verma, Chandra, Spring, David R., Itzhaki, Laura S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820706/
https://ncbi.nlm.nih.gov/pubmed/27046077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23732
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados