Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

Gankyrin is an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. Elevated gankyrin levels are linked to aberrant cellular events including enhanced degradation of tumour suppressor protein p53, and inhibition of gankyrin activity has therefo...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Chattopadhyay, Anasuya, O’Connor, Cornelius J., Zhang, Fengzhi, Galvagnion, Celine, Galloway, Warren R. J. D., Tan, Yaw Sing, Stokes, Jamie E., Rahman, Taufiq, Verma, Chandra, Spring, David R., Itzhaki, Laura S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820706/
https://ncbi.nlm.nih.gov/pubmed/27046077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23732
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