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Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
Gankyrin is an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. Elevated gankyrin levels are linked to aberrant cellular events including enhanced degradation of tumour suppressor protein p53, and inhibition of gankyrin activity has therefo...
Zapisane w:
| Wydane w: | Sci Rep |
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| Główni autorzy: | , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group
2016
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4820706/ https://ncbi.nlm.nih.gov/pubmed/27046077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23732 |
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