Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

Intracellular α-synuclein deposits, known as Lewy bodies, have been linked to a range of neurodegenerative disorders, including Parkinson’s disease. α-Synuclein binds to synthetic and biological lipids, and this interaction has been shown to play a crucial role for both α-synuclein’s native function...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Galvagnion, Céline, Brown, James W. P., Ouberai, Myriam M., Flagmeier, Patrick, Vendruscolo, Michele, Buell, Alexander K., Sparr, Emma, Dobson, Christopher M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Physical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932957/
https://ncbi.nlm.nih.gov/pubmed/27298346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601899113
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