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Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation
Parkinson’s disease is a highly debilitating neurodegenerative condition whose pathological hallmark is the presence in nerve cells of proteinacious deposits, known as Lewy bodies, composed primarily of amyloid fibrils of α-synuclein. Several missense mutations in the gene encoding α-synuclein have...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5027465/ https://ncbi.nlm.nih.gov/pubmed/27573854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604645113 |
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