Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation

Parkinson’s disease is a highly debilitating neurodegenerative condition whose pathological hallmark is the presence in nerve cells of proteinacious deposits, known as Lewy bodies, composed primarily of amyloid fibrils of α-synuclein. Several missense mutations in the gene encoding α-synuclein have...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Flagmeier, Patrick, Meisl, Georg, Vendruscolo, Michele, Knowles, Tuomas P. J., Dobson, Christopher M., Buell, Alexander K., Galvagnion, Céline
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027465/
https://ncbi.nlm.nih.gov/pubmed/27573854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604645113
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