A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

The self-assembly of α-synuclein is closely associated with Parkinson’s disease and related syndromes. We show that squalamine, a natural product with known anticancer and antiviral activity, dramatically affects α-synuclein aggregation in vitro and in vivo. We elucidate the mechanism of action of s...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Perni, Michele, Galvagnion, Céline, Maltsev, Alexander, Meisl, Georg, Müller, Martin B. D., Challa, Pavan K., Kirkegaard, Julius B., Flagmeier, Patrick, Cohen, Samuel I. A., Cascella, Roberta, Chen, Serene W., Limbocker, Ryan, Sormanni, Pietro, Heller, Gabriella T., Aprile, Francesco A., Cremades, Nunilo, Cecchi, Cristina, Chiti, Fabrizio, Nollen, Ellen A. A., Knowles, Tuomas P. J., Vendruscolo, Michele, Bax, Adriaan, Zasloff, Michael, Dobson, Christopher M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2017
Aiheet:
PNAS Plus
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307473/
https://ncbi.nlm.nih.gov/pubmed/28096355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610586114
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