A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

The self-assembly of α-synuclein is closely associated with Parkinson’s disease and related syndromes. We show that squalamine, a natural product with known anticancer and antiviral activity, dramatically affects α-synuclein aggregation in vitro and in vivo. We elucidate the mechanism of action of s...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Perni, Michele, Galvagnion, Céline, Maltsev, Alexander, Meisl, Georg, Müller, Martin B. D., Challa, Pavan K., Kirkegaard, Julius B., Flagmeier, Patrick, Cohen, Samuel I. A., Cascella, Roberta, Chen, Serene W., Limbocker, Ryan, Sormanni, Pietro, Heller, Gabriella T., Aprile, Francesco A., Cremades, Nunilo, Cecchi, Cristina, Chiti, Fabrizio, Nollen, Ellen A. A., Knowles, Tuomas P. J., Vendruscolo, Michele, Bax, Adriaan, Zasloff, Michael, Dobson, Christopher M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307473/
https://ncbi.nlm.nih.gov/pubmed/28096355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610586114
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