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A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
The self-assembly of α-synuclein is closely associated with Parkinson’s disease and related syndromes. We show that squalamine, a natural product with known anticancer and antiviral activity, dramatically affects α-synuclein aggregation in vitro and in vivo. We elucidate the mechanism of action of s...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5307473/ https://ncbi.nlm.nih.gov/pubmed/28096355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610586114 |
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