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Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins

Antibodies are powerful tools in life sciences research, as well as in diagnostic and therapeutic applications, because of their ability to bind given molecules with high affinity and specificity. Using current methods, however, it is laborious and sometimes difficult to generate antibodies to targe...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Sormanni, Pietro, Aprile, Francesco A., Vendruscolo, Michele
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538631/
https://ncbi.nlm.nih.gov/pubmed/26216991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422401112
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