Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

Antibodies targeting Aβ42 are under intense scrutiny because of their therapeutic potential for Alzheimer’s disease. To enable systematic searches, we present an “antibody scanning” strategy for the generation of a panel of antibodies against Aβ42. Each antibody in the panel is rationally designed t...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Aprile, Francesco A., Sormanni, Pietro, Perni, Michele, Arosio, Paolo, Linse, Sara, Knowles, Tuomas P. J., Dobson, Christopher M., Vendruscolo, Michele
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2017
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479649/
https://ncbi.nlm.nih.gov/pubmed/28691099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1700488
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