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Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
Antibodies targeting Aβ42 are under intense scrutiny because of their therapeutic potential for Alzheimer’s disease. To enable systematic searches, we present an “antibody scanning” strategy for the generation of a panel of antibodies against Aβ42. Each antibody in the panel is rationally designed t...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5479649/ https://ncbi.nlm.nih.gov/pubmed/28691099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1700488 |
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