Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

The aggregates of the Aβ peptide associated with Alzheimer’s disease are able to both grow in size as well as generate, through secondary nucleation, new small oligomeric species, that are major cytotoxins associated with neuronal death. Despite the importance of these amyloid fibril-dependent proce...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Scheidt, Tom, Łapińska, Urszula, Kumita, Janet R., Whiten, Daniel R., Klenerman, David, Wilson, Mark R., Cohen, Samuel I. A., Linse, Sara, Vendruscolo, Michele, Dobson, Christopher M., Knowles, Tuomas P. J., Arosio, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469941/
https://ncbi.nlm.nih.gov/pubmed/31001578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau3112
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