Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

The aggregates of the Aβ peptide associated with Alzheimer’s disease are able to both grow in size as well as generate, through secondary nucleation, new small oligomeric species, that are major cytotoxins associated with neuronal death. Despite the importance of these amyloid fibril-dependent proce...

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Udgivet i:Sci Adv
Main Authors: Scheidt, Tom, Łapińska, Urszula, Kumita, Janet R., Whiten, Daniel R., Klenerman, David, Wilson, Mark R., Cohen, Samuel I. A., Linse, Sara, Vendruscolo, Michele, Dobson, Christopher M., Knowles, Tuomas P. J., Arosio, Paolo
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2019
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469941/
https://ncbi.nlm.nih.gov/pubmed/31001578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau3112
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