Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

The aggregates of the Aβ peptide associated with Alzheimer’s disease are able to both grow in size as well as generate, through secondary nucleation, new small oligomeric species, that are major cytotoxins associated with neuronal death. Despite the importance of these amyloid fibril-dependent proce...

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Detaylı Bibliyografya
Yayımlandı:Sci Adv
Asıl Yazarlar: Scheidt, Tom, Łapińska, Urszula, Kumita, Janet R., Whiten, Daniel R., Klenerman, David, Wilson, Mark R., Cohen, Samuel I. A., Linse, Sara, Vendruscolo, Michele, Dobson, Christopher M., Knowles, Tuomas P. J., Arosio, Paolo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Association for the Advancement of Science 2019
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469941/
https://ncbi.nlm.nih.gov/pubmed/31001578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau3112
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