Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors

Understanding the mechanism of action of compounds capable of inhibiting amyloid-fibril formation is critical to the development of potential therapeutics against protein-misfolding diseases. A fundamental challenge for progress is the range of possible target species and the disparate timescales in...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Michaels, Thomas C. T., Šarić, Andela, Meisl, Georg, Heller, Gabriella T., Curk, Samo, Arosio, Paolo, Linse, Sara, Dobson, Christopher M., Vendruscolo, Michele, Knowles, Tuomas P. J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533883/
https://ncbi.nlm.nih.gov/pubmed/32929030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006684117
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