Distinct thermodynamic signature of oligomer generation in the aggregation of the amyloid-β peptide

Mapping energy landscapes has proved to be a powerful tool for studying reaction mechanisms. Many complex biomolecular assembly processes, however, have remained challenging to access using this approach, including the aggregation of peptides and proteins into amyloid fibrils implicated in various d...

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Udgivet i:Nat Chem
Main Authors: Cohen, Samuel I. A., Cukalevski, Risto, Michaels, Thomas. C. T., Šarić, Anđela, Törnquist, Mattias, Vendruscolo, Michele, Dobson, Christopher M., Buell, Alexander K., Knowles, Tuomas P. J., Linse, Sara
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5911155/
https://ncbi.nlm.nih.gov/pubmed/29581486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-018-0023-x
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