Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils

The nucleation of Alzheimer-associated Aβ peptide monomers can be catalyzed by preexisting Aβ fibrils. This leads to autocatalytic amplification of aggregate mass and underlies self-replication and generation of toxic oligomers associated with several neurodegenerative diseases. However, the nature...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Törnquist, Mattias, Cukalevski, Risto, Weininger, Ulrich, Meisl, Georg, Knowles, Tuomas P. J., Leiding, Thom, Malmendal, Anders, Akke, Mikael, Linse, Sara
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260961/
https://ncbi.nlm.nih.gov/pubmed/32439711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1918481117
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