Preventing peptide and protein misbehavior

di Arosio, Paolo, Meisl, Georg, Andreasen, Maria, Knowles, Tuomas P. J.
Pubblicato in Proc Natl Acad Sci U S A (2015)

Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide

di Meisl, Georg, Yang, Xiaoting, Frohm, Birgitta, Knowles, Tuomas P. J., Linse, Sara
Pubblicato in Sci Rep (2016)

An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation

di Yates, Emma V., Meisl, Georg, Knowles, Tuomas P. J., Dobson, Christopher M.
Pubblicato in J Phys Chem B (2016)

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants

di Meisl, Georg, Yang, Xiaoting, Dobson, Christopher M., Linse, Sara, Knowles, Tuomas P. J.
Pubblicato in Chem Sci (2017)

On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations

di Yang, Xiaoting, Meisl, Georg, Frohm, Birgitta, Thulin, Eva, Knowles, Tuomas P. J., Linse, Sara
Pubblicato in Proc Natl Acad Sci U S A (2018)

Mechanism of Fibril and Soluble Oligomer Formation in Amyloid Beta and Hen Egg White Lysozyme Proteins

di Perez, Carlos, Miti, Tatiana, Hasecke, Filip, Meisl, Georg, Hoyer, Wolfgang, Muschol, Martin, Ullah, Ghanim
Pubblicato in J Phys Chem B (2019)

The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils

di Thacker, Dev, Sanagavarapu, Kalyani, Frohm, Birgitta, Meisl, Georg, Knowles, Tuomas P. J., Linse, Sara
Pubblicato in Proc Natl Acad Sci U S A (2020)

Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells

di Sang, Jason C., Hidari, Eric, Meisl, Georg, Ranasinghe, Rohan T., Spillantini, Maria Grazia, Klenerman, David
Pubblicato in Commun Biol (2021)

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution

di Taylor, Christopher G., Meisl, Georg, Horrocks, Mathew H., Zetterberg, Henrik, Knowles, Tuomas P. J., Klenerman, David
Pubblicato in Anal Chem (2018)

Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans

di Sinnige, Tessa, Meisl, Georg, Michaels, Thomas C. T., Vendruscolo, Michele, Knowles, Tuomas P. J., Morimoto, Richard I.
Pubblicato in Proc Natl Acad Sci U S A (2021)

Diffuse transition state structure for the unfolding of a leucine-rich repeat protein

di Kelly, Sadie E., Meisl, Georg, Rowling, Pamela J. E., McLaughlin, Stephen H., Knowles, Tuomas, Itzhaki, Laura S.
Pubblicato in Phys Chem Chem Phys (2014)

Oligomer Diversity during the Aggregation of the Repeat Region of Tau

di Kjaergaard, Magnus, Dear, Alexander J., Kundel, Franziska, Qamar, Seema, Meisl, Georg, Knowles, Tuomas P. J., Klenerman, David
Pubblicato in ACS Chem Neurosci (2018)

The catalytic nature of protein aggregation

di Dear, Alexander J., Meisl, Georg, Michaels, Thomas C. T., Zimmermann, Manuela R., Linse, Sara, Knowles, Tuomas P. J.
Pubblicato in J Chem Phys (2020)

Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation

di Flagmeier, Patrick, Meisl, Georg, Vendruscolo, Michele, Knowles, Tuomas P. J., Dobson, Christopher M., Buell, Alexander K., Galvagnion, Céline
Pubblicato in Proc Natl Acad Sci U S A (2016)

The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation

di Cukalevski, Risto, Yang, Xiaoting, Meisl, Georg, Weininger, Ulrich, Bernfur, Katja, Frohm, Birgitta, Knowles, Tuomas P. J., Linse, Sara
Pubblicato in Chem Sci (2015)

Identification of on- and off-pathway oligomers in amyloid fibril formation

di Dear, Alexander J., Meisl, Georg, Šarić, Anđela, Michaels, Thomas C. T., Kjaergaard, Magnus, Linse, Sara, Knowles, Tuomas P. J.
Pubblicato in Chem Sci (2020)

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

di Galvagnion, Céline, Buell, Alexander K., Meisl, Georg, Michaels, Thomas C.T., Vendruscolo, Michele, Knowles, Tuomas P.J., Dobson, Christopher M.
Pubblicato in Nat Chem Biol (2015)

On-chip measurements of protein unfolding from direct observations of micron-scale diffusion

di Zhang, Yuewen, Yates, Emma V., Hong, Liu, Saar, Kadi L., Meisl, Georg, Dobson, Christopher M., Knowles, Tuomas P. J.
Pubblicato in Chem Sci (2018)

Direct Observation of Murine Prion Protein Replication in Vitro

di Sang, Jason C., Meisl, Georg, Thackray, Alana M., Hong, Liu, Ponjavic, Aleks, Knowles, Tuomas P. J., Bujdoso, Raymond, Klenerman, David
Pubblicato in J Am Chem Soc (2018)

Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils

di Törnquist, Mattias, Cukalevski, Risto, Weininger, Ulrich, Meisl, Georg, Knowles, Tuomas P. J., Leiding, Thom, Malmendal, Anders, Akke, Mikael, Linse, Sara
Pubblicato in Proc Natl Acad Sci U S A (2020)