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Direct Observation of Murine Prion Protein Replication in Vitro

[Image: see text] Prions are believed to propagate when an assembly of prion protein (PrP) enters a cell and replicates to produce two or more fibrils, leading to an exponential increase in PrP aggregate number with time. However, the molecular basis of this process has not yet been established in d...

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Dettagli Bibliografici
Pubblicato in:J Am Chem Soc
Autori principali: Sang, Jason C., Meisl, Georg, Thackray, Alana M., Hong, Liu, Ponjavic, Aleks, Knowles, Tuomas P. J., Bujdoso, Raymond, Klenerman, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2018
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6225343/
https://ncbi.nlm.nih.gov/pubmed/30351023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b08311
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