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The use of PrP transgenic Drosophila to replace and reduce vertebrate hosts in the bioassay of mammalian prion infectivity

Prion diseases are fatal neurodegenerative conditions of humans and vertebrate species. The transmissible prion agent is a novel infectious particle composed principally of PrP (Sc), an abnormal isomer of the normal host protein PrP (C). The only reliable method to detect mammalian prion infectivity...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:F1000Res
Prif Awduron: Thackray, Alana M., Andréoletti, Olivier, Bujdoso, Raymond
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: F1000 Research Limited 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998032/
https://ncbi.nlm.nih.gov/pubmed/29946445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.14753.1
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