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The use of PrP transgenic Drosophila to replace and reduce vertebrate hosts in the bioassay of mammalian prion infectivity

Prion diseases are fatal neurodegenerative conditions of humans and vertebrate species. The transmissible prion agent is a novel infectious particle composed principally of PrP (Sc), an abnormal isomer of the normal host protein PrP (C). The only reliable method to detect mammalian prion infectivity...

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Udgivet i:F1000Res
Main Authors: Thackray, Alana M., Andréoletti, Olivier, Bujdoso, Raymond
Format: Artigo
Sprog:Inglês
Udgivet: F1000 Research Limited 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998032/
https://ncbi.nlm.nih.gov/pubmed/29946445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.14753.1
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