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Genetic human prion disease modelled in PrP transgenic Drosophila

Inherited human prion diseases, such as fatal familial insomnia (FFI) and familial Creutzfeldt–Jakob disease (fCJD), are associated with autosomal dominant mutations in the human prion protein gene PRNP and accumulation of PrP(Sc), an abnormal isomer of the normal host protein PrP(C), in the brain o...

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Dades bibliogràfiques
Publicat a:Biochem J
Autors principals: Thackray, Alana M., Cardova, Alzbeta, Wolf, Hanna, Pradl, Lydia, Vorberg, Ina, Jackson, Walker S., Bujdoso, Raymond
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606059/
https://ncbi.nlm.nih.gov/pubmed/28814578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170462
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