Genetic human prion disease modelled in PrP transgenic Drosophila

Inherited human prion diseases, such as fatal familial insomnia (FFI) and familial Creutzfeldt–Jakob disease (fCJD), are associated with autosomal dominant mutations in the human prion protein gene PRNP and accumulation of PrP(Sc), an abnormal isomer of the normal host protein PrP(C), in the brain o...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Thackray, Alana M., Cardova, Alzbeta, Wolf, Hanna, Pradl, Lydia, Vorberg, Ina, Jackson, Walker S., Bujdoso, Raymond
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606059/
https://ncbi.nlm.nih.gov/pubmed/28814578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170462
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