Genetic human prion disease modelled in PrP transgenic Drosophila

Inherited human prion diseases, such as fatal familial insomnia (FFI) and familial Creutzfeldt–Jakob disease (fCJD), are associated with autosomal dominant mutations in the human prion protein gene PRNP and accumulation of PrP(Sc), an abnormal isomer of the normal host protein PrP(C), in the brain o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochem J
Prif Awduron: Thackray, Alana M., Cardova, Alzbeta, Wolf, Hanna, Pradl, Lydia, Vorberg, Ina, Jackson, Walker S., Bujdoso, Raymond
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Portland Press Ltd. 2017
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606059/
https://ncbi.nlm.nih.gov/pubmed/28814578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170462
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