Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans

Protein aggregation is associated with a wide range of degenerative human diseases with devastating consequences, as exemplified by Alzheimer’s, Parkinson’s, and Huntington’s diseases. In vitro kinetic studies have provided a mechanistic understanding of the aggregation process at the molecular leve...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sinnige, Tessa, Meisl, Georg, Michaels, Thomas C. T., Vendruscolo, Michele, Knowles, Tuomas P. J., Morimoto, Richard I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980373/
https://ncbi.nlm.nih.gov/pubmed/33836595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021888118
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