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Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans

Protein aggregation is associated with a wide range of degenerative human diseases with devastating consequences, as exemplified by Alzheimer’s, Parkinson’s, and Huntington’s diseases. In vitro kinetic studies have provided a mechanistic understanding of the aggregation process at the molecular leve...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Sinnige, Tessa, Meisl, Georg, Michaels, Thomas C. T., Vendruscolo, Michele, Knowles, Tuomas P. J., Morimoto, Richard I.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980373/
https://ncbi.nlm.nih.gov/pubmed/33836595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021888118
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