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Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides
The two major forms of the amyloid-beta (Aβ) peptide found in plaques in patients suffering from Alzheimer’s disease, Aβ40 and Aβ42, only differ by two amino acids in the C-terminal region, yet they display markedly different aggregation behavior. The origins of these differences have remained chall...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4084462/ https://ncbi.nlm.nih.gov/pubmed/24938782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401564111 |
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