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Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

The two major forms of the amyloid-beta (Aβ) peptide found in plaques in patients suffering from Alzheimer’s disease, Aβ40 and Aβ42, only differ by two amino acids in the C-terminal region, yet they display markedly different aggregation behavior. The origins of these differences have remained chall...

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Detalhes bibliográficos
Main Authors: Meisl, Georg, Yang, Xiaoting, Hellstrand, Erik, Frohm, Birgitta, Kirkegaard, Julius B., Cohen, Samuel I. A., Dobson, Christopher M., Linse, Sara, Knowles, Tuomas P. J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084462/
https://ncbi.nlm.nih.gov/pubmed/24938782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401564111
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