On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations

The aggregation of the amyloid-β (Aβ) peptide is linked to the pathogenesis of Alzheimer’s disease (AD). In particular, some point mutations within Aβ are associated with early-onset familial Alzheimer’s disease. Here we set out to explore how the physical properties of the altered side chains, incl...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Yang, Xiaoting, Meisl, Georg, Frohm, Birgitta, Thulin, Eva, Knowles, Tuomas P. J., Linse, Sara
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042101/
https://ncbi.nlm.nih.gov/pubmed/29895690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803539115
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