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On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations
The aggregation of the amyloid-β (Aβ) peptide is linked to the pathogenesis of Alzheimer’s disease (AD). In particular, some point mutations within Aβ are associated with early-onset familial Alzheimer’s disease. Here we set out to explore how the physical properties of the altered side chains, incl...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6042101/ https://ncbi.nlm.nih.gov/pubmed/29895690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803539115 |
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