Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans

The nematode worm Caenorhabditis elegans has emerged as an important model organism in the study of the molecular mechanisms of protein misfolding diseases associated with amyloid formation because of its small size, ease of genetic manipulation, and optical transparency. Obtaining a reliable and qu...

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Publicado en:ACS Chem Biol
Autores principales: Laine, Romain F., Sinnige, Tessa, Ma, Kai Yu, Haack, Amanda J., Poudel, Chetan, Gaida, Peter, Curry, Nathan, Perni, Michele, Nollen, Ellen A.A., Dobson, Christopher M., Vendruscolo, Michele, Kaminski Schierle, Gabriele S., Kaminski, Clemens F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612977/
https://ncbi.nlm.nih.gov/pubmed/31246415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00354
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