The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils

Crystals, nanoparticles, and fibrils catalyze the generation of new aggregates on their surface from the same type of monomeric building blocks as the parent assemblies. This secondary nucleation process can be many orders of magnitude faster than primary nucleation. In the case of amyloid fibrils a...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Thacker, Dev, Sanagavarapu, Kalyani, Frohm, Birgitta, Meisl, Georg, Knowles, Tuomas P. J., Linse, Sara
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568274/
https://ncbi.nlm.nih.gov/pubmed/33004626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002956117
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