Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid

Alzheimer’s disease is linked to amyloid β (Aβ) peptide aggregation in the brain, and a detailed understanding of the molecular mechanism of Aβ aggregation may lead to improved diagnostics and therapeutics. While previous studies have been performed in pure buffer, we approach the mechanism in vivo...

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Vydáno v:Commun Biol
Hlavní autoři: Frankel, Rebecca, Törnquist, Mattias, Meisl, Georg, Hansson, Oskar, Andreasson, Ulf, Zetterberg, Henrik, Blennow, Kaj, Frohm, Birgitta, Cedervall, Tommy, Knowles, Tuomas P. J., Leiding, Thom, Linse, Sara
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783456/
https://ncbi.nlm.nih.gov/pubmed/31602414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0612-2
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