Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid

Alzheimer’s disease is linked to amyloid β (Aβ) peptide aggregation in the brain, and a detailed understanding of the molecular mechanism of Aβ aggregation may lead to improved diagnostics and therapeutics. While previous studies have been performed in pure buffer, we approach the mechanism in vivo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Commun Biol
Prif Awduron: Frankel, Rebecca, Törnquist, Mattias, Meisl, Georg, Hansson, Oskar, Andreasson, Ulf, Zetterberg, Henrik, Blennow, Kaj, Frohm, Birgitta, Cedervall, Tommy, Knowles, Tuomas P. J., Leiding, Thom, Linse, Sara
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783456/
https://ncbi.nlm.nih.gov/pubmed/31602414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0612-2
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