Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid

Alzheimer’s disease is linked to amyloid β (Aβ) peptide aggregation in the brain, and a detailed understanding of the molecular mechanism of Aβ aggregation may lead to improved diagnostics and therapeutics. While previous studies have been performed in pure buffer, we approach the mechanism in vivo...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Frankel, Rebecca, Törnquist, Mattias, Meisl, Georg, Hansson, Oskar, Andreasson, Ulf, Zetterberg, Henrik, Blennow, Kaj, Frohm, Birgitta, Cedervall, Tommy, Knowles, Tuomas P. J., Leiding, Thom, Linse, Sara
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783456/
https://ncbi.nlm.nih.gov/pubmed/31602414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0612-2
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