Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid

Alzheimer’s disease is linked to amyloid β (Aβ) peptide aggregation in the brain, and a detailed understanding of the molecular mechanism of Aβ aggregation may lead to improved diagnostics and therapeutics. While previous studies have been performed in pure buffer, we approach the mechanism in vivo...

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Publicado en:Commun Biol
Autores principales: Frankel, Rebecca, Törnquist, Mattias, Meisl, Georg, Hansson, Oskar, Andreasson, Ulf, Zetterberg, Henrik, Blennow, Kaj, Frohm, Birgitta, Cedervall, Tommy, Knowles, Tuomas P. J., Leiding, Thom, Linse, Sara
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783456/
https://ncbi.nlm.nih.gov/pubmed/31602414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0612-2
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